Bone-Marrow Derived Stem Cells Protocol for Premature Ovarian Failure – A case study with successful spontaneous pregnancy and delivery after treatment
Published in Research Square Abstract OBJECTIVES Stem cell-based therapies are emerging enormously as a ray of hope and therapeutic alternative for ovarian rejuvenation, regeneration and follicular development in women with impaired ovaries mainly due to primary ovarian insufficiency or premature ovarian failures, the conditions which cannot be improved much medically or surgically. In the modern […]
Stem Cell Paracrine Signaling for Treatment of Premature Ovarian Insufficiency
Published in Frontiers In Endocrinology Abstract Premature ovarian insufficiency is a common disorder affecting young women and represents the worst-case ovarian scenario due to the substantial impact on the reproductive lifespan of these patients. Due to the complexity of this condition, which is not fully understood, non-effective treatments have yet been established for these patients. […]
In vitro follicular activation and stem cell therapy as a novel treatment strategies in Dismished ovarian reserve and primary ovarian insufficiency
Published in Frontiers In Endocrinology Abstract Usually poor ovarian response (POR) to gonadotropins reflects a diminished ovarian reserve (DOR) that gives place to few recruitable follicles despite aggressive stimulation. The reduction in the quantity and quality of the oocytes with advanced age is physiological. However, some women experience DOR much earlier and become prematurely infertile, […]
Role of autologous bone marrow derived stem cells and platelet rich plasma for endometrial regeneration and repair and ovarian rejuvenation
Published in International Journal of Reproduction, Contraception, Obstetrics and Gynecology Abstract Background: Stem cells are undifferentiated cells with a potential for self- renewal and differentiation into multiple mature cell types. PRP is blood plasma that has been enriched with platelets and multiple growth factors that can stimulate cellular processes and activate multi-potent stem cells to […]
Progress in human ovarian rejuvenation: Current platelet-rich plasma and condensed cytokine research activity by scope and international origin
Published in Clinical and Experimental Reproductive Medicine Abstract Objective As clinicians and patients await consensus on intraovarian platelet-rich plasma (PRP) treatment, this project evaluated contemporary research trends in the literature. Methods A PubMed/NLM search aggregated all ovarian PRP-related publications (n=54) to evaluate their scope, abstract utility, submission-to-publication interval, journal selected, article processing charge (APC), free […]
Ovarian Rejuvenation Using Autologous Platelet-Rich Plasma
Published in Endocrines Journal Abstract Advanced maternal age is associated with the natural oocyte depletion, leading to low oocyte yield, high infertility treatment cancellation rates, and eventual decreases in pregnancy rates. Various innovative interventions have been introduced to improve the outcome of infertility treatment for aging patients. Numerous published data demonstrated that early follicle development […]
Trial of Autologous Marrow derived Stem Cell Ovarian Transplantation (TAMSCOT) in young infertile women with diminished ovarian reserve for ovarian rejuvenation – HOPE still persists
Published in Human Reproduction Abstract Study question Does autologous bone marrow derived stem cell (BMDSC) ovarian transplantation optimize ovarian reserve parameters in young infertile women with diminished ovarian reserve (DOR) ? Summary answer The autologous stem cell ovarian transplantation (ASCOT) improves AFC and AMH by facilitating the recruitment of existing dormant follicles in young women […]
Combined Use of Autologous Bone Marrow-derived Stem Cells and Platelet-rich Plasma for Ovarian Rejuvenation in Poor Responders
Published in Journal of Human Reproductive Sciences Abstract Background: The management of poor responders is still a challenge in modern-assisted reproductive technology. Several researches show encouraging results with individual autologous bone marrow-derived stem cells (ABMDSCs) and platelet-rich plasma (PRP). Hence, we decided to study the synergistic effect of ABMDSCs with PRP. Aims and Objective: The […]
Autologous ovarian in vitro activation with ultrasound-guided orthotopic re-transplantation
Abstract Reduction of the number of primordial follicles, associated with cellular and molecular damage of the ovarian tissue, leads to failure of ovarian function and, ultimately, to menopause. It has been proven that the ovarian fragmentation leads to the interruption of Hippo signaling pathway, thereby leading to promotion of follicular growth. It has been shown […]
Implantation and the Fetal Health – Chapter 4
Published in Implantation and the Fetal Health. Induced Abortion and Spontaneous Early Pregnancy Loss – Focus on Management Abstract Implantation is one of the crucial periods in human reproduction. Increasing body of evidence suggests that the improper (dysfunctional) implantation and the formation of the placenta can endanger life and health of both the fetus and […]