PERFORMING DOS ovarian rejuvenation

Dual SEGOVA (DOS) represents a cutting-edge and unparalleled approach to ovarian rejuvenation, utilizing a combination of autologous mesenchymal and hematopoietic stem cells, alongside in vitro ovarian tissue activation.

Key Components of Dual SEGOVA Therapy:

hc PRP – Highly concentrated platelet growth factors
BRF – Bio-Regenerative Fibrin
BM mSC – Bone Marrow-derived mesenchymal Stem Cells
hSC – hematopoietic Stem Cells
IVA – In Vitro Activated ovarian tissue
Metabolic and physical optimization – personalized nutrition and training
TPE – Therapeutic Plasma Exchange

Dual SEGOVA (DOS) Process Step-by-Step

Pre-Arrival Coordination

Before traveling, the patient receives personalized assistance, including:

Initial Consultation (Online or Local Partner Clinic)
- Comprehensive review of medical history
- Explanation of the Dual SEGOVA procedure and expected outcomes
- Discussion of necessary pre-travel medical tests
Travel and Accommodation Planning
- Assistance in booking flights and accommodations
- Guidance on visa and entry requirements
- Transportation arrangements from the airport to the hotel/apartment or medical facility
Medical Documentation Preparation
- Coordination with the medical team to review required lab results
- Remote pre-procedure consultation with specialists

Arrival & Preoperative Evaluation

Day 0-1: Arrival & Preoperative Evaluation

Airport Pickup and Check-in
- Meet-and-greet at the airport with private transfer to the hotel or clinic
Comprehensive Medical Examination
- Preoperative Medical Evaluation
Patient Orientation Session
- Detailed discussion on the upcoming procedure
- Introduction to the medical team and facility tour
Personalized Nutritional and Lifestyle Optimization
- Consultation with a pharmacist/nutritionist to optimize metabolic health
- Recommendations for HIIT (high-intensity interval training) to be initiated two weeks post-procedure for ovarian function enhancement / Physiotherapist

HOSPITAL STAY

Day 2-3: Dual SEGOVA Procedure (Hospital Stay: 1–2 Days)

Hospital Admission & Pre-Surgical Preparations
- Final medical check-up and surgical consent
- Preoperative bowels preparation and medication
- Preparation by the anesthesia team
Procedure
- Blood collection for PRP and BRF isolation using an automated system
- Bone marrow aspiration from the iliac bone
- Processing of mesenchymal and hematopoietic stem cells using fully automated closed system
- Laparoscopic ovarian cortex excision
- Hemostasis control with biological agents (BRF)
- Tissue fragmentation and in vitro tissue processing with hc PRP
- Creation of subcortical tunnels
- Application of BRF scaffold
- Reimplantation of mSC, hSC, GCFS and IVA tissue with hc PRP
- Reconstruction of the ovarian cortex with bio-regenerative BRF
- Final visual control and hemostasis verification
- Cryopreservation of the stem cells surplus for future use
- TPE (Therapeutic Plasma Exchange)
- Face PRP and O-shot (as a bonus)
Post-Surgical Monitoring and Recovery
- Continuous observation in a recovery suite
- Pain management and initial mobility support

hospital discharge

Day 4: Hospital Discharge & Early Recovery

Final Postoperative Assessment
- Post-surgical ultrasound evaluation
- Discharge summary with personalized recovery guidelines
- Prescription for medications and supplements
Transfer to Hotel for Continued Recovery
- Private transport to accommodation
- 24/7 medical support availability

postoperative support

Day 5-7: Early Recovery & Postoperative Support

Rest & Rehabilitation
- Personalized post-surgical diet
- Continued pain management and hydration monitoring
- Daily telemedicine check-ins with medical staff
- Check-up by the medical team to assess recovery progress
Light Physical Activity
- Initiation of gentle mobility exercises
Departure
- Airport transfer from the hotel or apartment for a seamless journey home.

remote monitoring & recovery optimization

Week 2-4: Recovery Optimization & Gradual Physical Activity

Introduction of HIIT-Based Training
- Customized HIIT-based physical activity for ovarian function enhancement begins at least two weeks post-procedure
Personalized Fertility Support
- Detailed reproductive monitoring plan
- Consultation on ultrasound and laboratory assessments at recommended intervals
- Consideration of IVF or natural conception strategies

ongoing support

Ongoing Support & Long-Term Fertility Planning

Quarterly Follow-Up Assessments
- Hormonal profile and ovarian function monitoring
- Metabolic and nutritional guidance
Fertility Assistance (If Needed)
- Customized reproductive care plan, including IVF support if necessary
- Coordination with fertility specialists
Long-Term Wellness & Optimization
- Guidance on maintaining ovarian health
- Lifestyle modifications for enhanced reproductive outcomes

Why Choose SEGOVA?

Cutting-Edge Science & Innovation

Pioneering research led by Prof. Dr. Aleksandar Ljubić, a global leader in ovarian rejuvenation.
Exclusive, next-generation therapies using PRP, two types of stem cells, and in vitro ovarian activation.
Therapeutic plasma exchange (TPE)
Bonus Face PRP and O-shot

Personalized, Patient-Centered Care

Tailored treatment plans designed to align with each patient’s reproductive goals and ovarian health.
Comprehensive patient support, from initial consultation to post-treatment follow-up.

Seamless International Patient Experience

Full-service coordination, including travel, accommodation, paperwork, and medical scheduling and paperwork.
Multilingual support to ensure a smooth and stress-free treatment journey.

Proven Success & Long-Term Benefits

Effective fertility restoration for patients with premature ovarian failure, failed IVF cycles, and age-related infertility.
Minimally invasive procedures with shorter recovery times and minimally invasive, high precision.