PERFORMING Bio IVF

Bio IVF serves as the initial stage in ovarian rejuvenation treatments. At its core is the use of highly concentrated autologous activated platelet-derived growth factors (hc PRP). This therapeutic approach is typically administered during ovarian stimulation, with intra-ovarian injections carried out in the early phase of the menstrual cycle.

Key Components of Bio IVF Therapy:

hc PRP – Highly concentrated platelet growth factors
BRF – Bio-Regenerative Fibrin
TPE – Therapeutical Plasma Exchange

There are three levels of Bio IVF Therapy:

Bio IVF Basic utilizes hc PRP to deliver these potent autologous growth factors.
Bio IVF Medium enhances the effect by combining hc PRP with a natural, patient-derived fibrin matrix known as Bioregenerative Fibrin (BRF).
Bio IVF Advanced further includes Therapeutic Plasma Exchange (TPE) for metabolic optimization, alongside hc PRP and BRF.

Bio IVF Basic intrauterine / intraovarian hc PRP application

This approach utilizes the newest generation of autologous, activated, and highly concentrated growth factors (hc PRP), administered directly into the ovaries and endometrium. The treatment is conducted as a single-day procedure, ideally between day 2 and 4 of the menstrual cycle.

Bio IVF Basic process step-by-step

Single-day hospital procedure

Collection of a blood sample to isolate growth factors
Processing and enrichment of the sample to concentrate platelets and bioactive growth factors
Preparation of the autologous thrombin-based activator
Ultrasound-guided intraovarian injections of hc PRP, along with FSH, FSH/LH, GH, and hCG
Ultrasound-guided delivery of hc PRP and hCG into the uterus: including transmyometrial, subendometrial, and intracavitary routes
Ongoing fertility support provided by the SEGOVA medical team

Bio IVF Medium intrauterine / intraovarian hc prp with BRF

This advanced treatment combines next-generation autologous, activated, highly concentrated platelet-derived growth factors (hc PRP) with a bioregenerative fibrin matrix (BRF) for enhanced ovarian and endometrial support. The procedure is completed in a single day, typically between cycle days 2 and 4.

Bio IVF Medium process step-by-step

Single-day hospital procedure

Collection of a blood sample for growth factor processing
Processing and enrichment of the sample to concentrate platelets and bioactive growth factors
Isolation of the bioregenerative fibrin matrix (BRF)
Preparation of autologous thrombin as an activator
Ultrasound-guided ovarian injections of the BRF matrix combined with hc PRP, along with FSH, FSH/LH, GH, and hCG
Ultrasound-guided uterine administration of hc PRP and hCG with BRF matrix via transmyometrial, subendometrial, and intracavitary approaches
Ongoing fertility care and coordination by the SEGOVA medical team

Bio IVF Advanced intrauterine / intraovarian hc prp with BRF & TPE

This comprehensive treatment integrates Therapeutic Plasma Exchange (TPE) with autologous activated highly concentrated platelet-derived growth factors (hc PRP) and the bioregenerative fibrin matrix (BRF) for enhanced ovarian and endometrial rejuvenation. The entire protocol is completed within a single day, usually scheduled between cycle days 2 and 4.

Bio IVF Adbanced process step-by-step

Single-day hospital procedure

Therapeutic Plasma Exchange (TPE): Establishing vascular access, initiating extracorporeal circulation, removing plasma, introducing supportive replacement fluids, followed by centrifugation and reinfusion
Collection of a blood sample to isolate regenerative growth factors (hc PRP)
Processing and enrichment of the sample to concentrate platelets and bioactive growth factors
Extraction of the bioregenerative fibrin matrix (BRF)
Preparation of autologous thrombin for activation
Ultrasound-guided ovarian administration of BRF, hc PRP, FSH or FSH/LH, GH, and hCG
Ultrasound-guided uterine delivery of hc PRP, hCG, and BRF through transmyometrial, subendometrial, and intracavitary routes
· Comprehensive fertility support provided by the SEGOVA medical team

Why Choose SEGOVA?

Cutting-Edge Science & Innovation

Pioneering research led by Prof. Dr. Aleksandar Ljubić, a global leader in ovarian rejuvenation.
Exclusive, next-generation therapies using PRP, two types of stem cells, and in vitro ovarian activation.
Therapeutic plasma exchange (TPE)
Bonus Face PRP and O-shot

Personalized, Patient-Centered Care

Tailored treatment plans designed to align with each patient’s reproductive goals and ovarian health.
Comprehensive patient support, from initial consultation to post-treatment follow-up.

Seamless International Patient Experience

Full-service coordination, including travel, accommodation, paperwork, and medical scheduling and paperwork.
Multilingual support to ensure a smooth and stress-free treatment journey.

Proven Success & Long-Term Benefits

Effective fertility restoration for patients with premature ovarian failure, failed IVF cycles, and age-related infertility.
Minimally invasive procedures with shorter recovery times and minimally invasive, high precision.

Contact our team to learn more about how we can assist you.