PERFORMING SEGO Ovarian Rejuvenation

SEGO – STEM CELL THERAPY is an autologous ovarian rejuvenation procedure, performed through a structured ovarian rejuvenation approach, Intra-ovarian application of the latest generation of highly concentrated growth factors (hc PRP) with a bio-regenerative fibrin (BRF) scaffold and mobilized apheresis-derived stem cells (MASC).

Key Components of SEGO Therapy:

hc PRP – Highly concentrated platelet growth factors
BRF – Bio-Regenerative Fibrin
MASC – Mobilized apheresis-derived stem cells
Metabolic and physical optimization – Personalized nutrition and training

Important: The SEGO procedure can also be organized in the form of two shorter two-day stays. In that case, preparation and analysis would be done during the first visit, so that preparatory therapy – mobilization – could be planned. During the second visit, a daily apheresis and retransplantation procedure would be performed.

SEGO PROCESS STEP-BY-STEP

Pre-Arrival Coordination

Before traveling, the patient receives personalized assistance, including:

Initial Online Consultation
- Comprehensive review of medical history
- Explanation of SEGO procedure and expected outcomes
- Discussion of necessary pre-travel medical tests
Travel and Accommodation Planning
- Assistance in booking flights and accommodations
- Guidance on visa and entry requirements
- Transportation arrangements from the airport to the hotel/apartment or medical facility
Medical Documentation Preparation
- Coordination with the medical team to review required lab results
- Remote pre-procedure consultation with specialists

ARRIVAL & preoperative evaluation

Day 0: Arrival

Airport Pickup and Check-in
- Meet-and-greet at the airport with private transfer to the hotel or clinic

Day 1: Preoperative Evaluation

Comprehensive Medical Examination
- Necessary hormonal, metabolic, genetic, and immunological analyses
- Assessment of vitamin, oxydo-reduction, microelement and heavy metal levels
- Preoperative medical assessment
Patient Orientation Session
- Detailed discussion on the upcoming procedure
- Introduction to the medical team and facility tour
Personalized Nutritional and Lifestyle Optimization
- Consultation with a pharmacist/nutritionist to optimize metabolic health
- Recommendations for HIIT (high-intensity interval training) to be initiated two weeks post-procedure for ovarian function enhancement / Physiotherapist

Pre-Operative Preparations & Procedure

Day 1-4: Pre-Surgical Preparations

Pre-Surgical Preparations
- Final medical check-up and surgical consent
- Preparation by the anesthesia team
- Medication for SC mobilisation: day 1-4

Day 4 – Procedure (Daily procedure – No Overnight Hospital Stay)

Blood sample processing to extract growth factors: Optimization with platelet and growth factor concentration; Isolation of bio-regenerative fibrin (scaffold); Preparation of autologous thrombin
Pre-procedure analysis, Apheresis; Processing and optimization of apheresis-derived stem cells
Ultrasound guided – Creation of subcortical ovarian tunnels; Application of autologous activated BRF scaffold; Re-transplantation of MASC, GCSF and hc PRP, Hemostasis with BRF
Optional cryopreservation of excess stem cells
Initial visit with a nutritionist
Initial visit with a physiotherapist
Continuous observation in a recovery suite
Pain management and initial mobility support

discharge

Day 4: Discharge & Recovery

Final Postoperative Assessment
- Post-surgical ultrasound evaluation
- Discharge summary with personalized recovery guidelines
- Prescription for medications and supplements
Transfer to Hotel/Apartment for Continued Recovery
- Private transport to accommodation
- 24/7 medical support availability

postoperative support

Day 5-6: Early Recovery & Postoperative Support

Rest & Rehabilitation
- Personalized post-surgical diet
- Continued pain management and hydration monitoring
- Daily telemedicine check-ins with medical staff
- Check-up by the medical team to assess recovery progress
Light Physical Activity
- Initiation of gentle mobility exercises
Departure
- Airport transfer from the hotel or apartment for a seamless journey home.

remote monitoring & recovery optimization

Week 2-4: Recovery Optimization & Gradual Physical Activity

Introduction of HIIT-Based Training
- Customized HIIT-based physical activity for ovarian function enhancement begins at least two weeks post-procedure
Regular Follow-Ups
- Hormonal/ultrasound monitoring (the patient is advised to do monthly check-ups)
- Virtual consultations when needed
Personalized Fertility Support
- Detailed reproductive monitoring plan
- Consultation on ultrasound and laboratory assessments at recommended intervals
- Consideration of IVF or natural conception strategies

ongoing support

Ongoing Support & Long-Term Fertility Planning

Quarterly Follow-Up Assessments
- Hormonal profile and ovarian function monitoring
- Metabolic and nutritional guidance
Fertility Assistance (If Needed)
- Customized reproductive care plan, including IVF support if necessary
- Coordination with fertility specialists
Long-Term Wellness & Optimization
- Guidance on maintaining ovarian health
- Lifestyle modifications for enhanced reproductive outcomes

Why Choose SEGOVA?

Cutting-Edge Science & Innovation

Pioneering research led by Prof. Dr. Aleksandar Ljubić, a global leader in ovarian rejuvenation.
Exclusive, next-generation therapies using PRP, stem cells, and in vitro ovarian activation.

Personalized, Patient-Centered Care

Tailored treatment plans designed to align with each patient’s reproductive goals and ovarian health.
Comprehensive patient support, from initial consultation to post-treatment follow-up.

Seamless International Patient Experience

Full-service coordination, including travel, accommodation, paperwork, and medical scheduling and paperwork.
Multilingual support to ensure a smooth and stress-free treatment journey.

Proven Success & Long-Term Benefits

Effective fertility restoration for patients with premature ovarian failure, failed IVF cycles, and age-related infertility.
Minimally invasive procedures with shorter recovery times and minimally invasive, high precision.

Contact our team to learn more about how we can assist you.