Preparation for the procedure consists in analyzing the patient’s overall state and confirming normal ovary appearance. Hence, hormone, immunologic and infective status is determined and tumour markers are checked through blood tests.
If all conditions are fulfilled, the procedure can be performed and it involves several steps.
1. In the first phase, bone marrow cells are extracted from the tibia, the lower leg bone. This procedure is carried out under general or local anesthesia.
2. During the next phase stem cells are prepared, identified and differentiated (these cells are of Mesenchymal origin, as are ovarian cells).
3. Preparation for the next phase includes measuring ovarian volume and vascularization, identifying indices which help us plan for the next stage.
4. Last phase, installation, consists of the ultrasound-guided injection of stem cells in specific parts of the ovaries where eggs are produced. To do so, we map blood vessel. This intervention is carried out under general or local anaesthesia.
If we combine SCOR treatment with PLRP ovarian rejuvenation (intro ovarian injection of platelet-rich plasma – PLRP), we need to prepare the PLRP before the last phase of SCOR, after we have obtained stem cells.
The first step of PLRP is to obtain an adequate amount of blood, depending on the patient’s built and the assessed ovarian insufficiency, clinical picture, and diagnosis, as well as the desired factor combination. Second stage or lab stage includes applying special technology which, using special separators and systems, divides and filters specific cells, prepares them and activates the growth factors inside them.
Preparation for the next phase includes measuring ovarian volume and vascularization, identifying indices which help us plan for the next stage. In the final phase of the combined SCOR and PLRP procedure, stem cells with growth factors are injected into specific parts of the ovaries.
TIMING OF THE PROCEDURE
If a woman still has a period, the procedure is carried out in the first half of the menstrual cycle, during menstrual bleeding or the several couples of days after menstruation. In patients who no longer have periods, the intervention is carried out when the conditions allow it after the lab tests and ultrasound examinations have been performed.
Possible complications are related to the injection of SC and PLRP into the ovary. The complication rate is less than 1% and can involve bleeding, punctures or injuries to the surrounding organs and complications with anaesthesia. Serious complications requiring hospital treatment are significantly less frequent.
Full effects are expected within 6 months. If the desired effect is a reproduction, in the period following SCOR/PLRP treatment, standard in vitro fertility treatments are performed in a natural, modified and stimulated cycle. We track all changes in the hormonal, immunological and reproductive parameters and closely follow and assess the results of the treatment.